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Public databases with primary data are ...
  a lot of work
  too much work
  not reliable due to lack of validation
Description of Work
MUGEN aims to structure and shape a world-class network of European scientific and technological excellence in the field of 'murine models of human immunological disease', to advance understanding of the genetic basis of disease and to enhance innovation and translatability of research efforts.

MUGEN's specific mission is to bring together different expertise from academic and industrial laboratories in order to study human immunological disease by integrating the participant's strengths in immunological knowledge with new approaches in functional genomics. In this way MUGEN expects to bring Europe a competitive advantage in the development of new diagnostic and therapeutic tools. In concert, MUGEN promotes training of young researchers and exploitation, dissemination and communication of scientific and technological excellence both within and outside of the network, to include all interested stakeholders in the area of human immunological diseases.

Moving towards the 4th JPA, MUGEN is focusing on further supporting already established capabilities, through greater integration of already set up services as well as investment on the development of new technological cores, expanding and enriching its research efforts and diversifying its dissemination initiatives to raise awareness.
Work packages
1. Transgensis / Gene Targeting Core Lead Participant - Fleming
Leading Scientist - Dr. George Kollias
2. Gene Expression Profiling Core Lead Participant - Genopolis
Leading Scientist - Prof. Paola Ricciardi - Castagnoli
3. Bioinformatics Core Lead Participant - EMBL
Leading Scientist - Dr. Alvis Brazma
4. Mugen Knowledge Environment (MKE) Lead Participant - Fleming
Leading Scientist - Dr. George Kollias
5. Relational Databases (MDE) Lead Participant - Arexis
Leading Scientist - Dr. Bjorn Lowenadler
6. Random Mutagenesis Lead Participant - FLEMING
Leading Scientist - Dr. George Kollias
7. Innate Immune Activation Lead Participant - Humanitas
Leading Scientist - Prof. Alberto Mantovani
8. Mechanisms of Antigen Recognition Lead Participant - CNRS
Leading Scientist - Dr. Bernard Malissen
9. Immunological Tolerance Lead Participant - EXPIMMZH
Leading Scientist - Dr. Maries van den Broek
10. Intracellular Signaling Cascades Affecting Innate and Acquired Immune Responses Lead Participant - IP
Leading Scientist - Dr. James Di Santo
3 Pages: 1, 2, 3
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